WebMapper: (Windows)
http://www.spinel.com
MapEdit: (Windows)
http://www.boutell.com/mapedit
HotSpots: (Windows)
http://www.cris.com/~automata/hotspots.shtml
WebMap: (Mac)
http://hyperarchive.lcs.mit.edu/HyperArchive /Archive/text/html/web-map-101.hqx
Image maps tools
http://www.ihip.com/tools.html
Note: Many web authoring applications have integrated graphics editing and image map capabilities.
